An interesting short article was published in the most recent edition of the international Journal of Pathology and medical research diagnosing what is believed to be the first known case of an individual having Chronic Traumatic Encephalopathy who did not have a history of concussions.

In the article, titled “Chronic Traumatic Encephalopathy-like Neuropathological Findings Without a history of Trauma” a 45 year old man who was found dead in his sleep had his brain analyzed post mortem and CTE like changes were revealed.  This was noteworthy to researchers as the client had no known history of head trauma.  The authors note as follows

To our knowledge, this is the Camiseta Selección de fútbol de Australia first description of a client with neuropathological features of CTE-MND in the absence of a history traumatic brain injury. Interestingly, despite cortical tau pathology, our client never exhibited cognitive impairment, which speculatively could be explained by the relative sparing of the nucleus basalis of Meynert. This highlights the uncertainty surrounding the pathogenesis and pathophysiology of CTE and underscores the need for even more comprehensive studies to elucidate the causative role of trauma. Nevertheless, our case report has several essential limitations. For example, the lack of a trauma history comes only from the recollection of the patient’s partner and early life subconcussive blows cannot be entirely excluded. There are also inherent limitations to drawing conclusions from the results of a single patient.

To date, repetitive traumatic brain injury has been shown to be associated Camiseta Liverpool FC with no neuropathological changes, with CTE alone, with -CTE and another neurodegenerative disease, or with non-CTE neurodegeneration. because CTE is a postmortem diagnosis, the majority of samples have come from brains of symptomatic individuals referred by family; these individuals are much more likely to demonstrate some type of neuropathology thus introducing a selection bias. Our case adds to this complexity given the observation that CTE-like changes can occur in Camiseta Sport Club Internacional the absence of any known head injury; casting doubt that trauma is always the inciting etiological factor. Future studies ought to evaluate whether CTE-like pathology is prevalent in non-concussed client populations.

The full short article can be found here.

 

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